The majority of patients rated MIEBO as
COMFORTABLE OR VERY COMFORTABLE
on instillation*
The MIEBO experience
IN GOBI AND MOJAVE PIVOTAL TRIALS1:
IN THE KALAHARI STUDY2:
The majority of patients‡:
Were satisfied with MIEBO treatment
-
Found MIEBO comfortable
-
Said MIEBO was easy to administer
Most patients (~94%) were considered compliant with dosing throughout the study†
Only ~5% of patients (n = 10) used adjunctive artificial tears/mineral oil, as permitted, after Week 4
IN THE PHASE 4 STUDY3:
-
Consistently high patient satisfaction
-
At Day 14, median satisfaction score
increased to 90
Patient-reported treatment satisfaction
The feeling of first drop relief¶
Most patients described MIEBO as silky, smooth, and soothing
SD, standard deviation.
*Questionnaire was given on Day 1 of the GOBI and MOJAVE studies. Mean pooled comfort score was 8.0 for MIEBO and 8.4 for saline (scale of 0-10, 0 = not comfortable and 10 = very comfortable). 81% of patients treated with MIEBO reported a score of 7 or higher.1
†Mean Visual Analog Scale (VAS) score (SD) was assessed at Week 52. Respondents rated MIEBO with the following scores (scale of 0-10): satisfaction, 8.0 (2.3); comfort, 8.4 (2.1); ease of administration, 8.9 (1.9).2
‡Defined as administration of 80% to 120% of the expected doses.2
§Treatment satisfaction was rated on a VAS from 0 (extremely dissatisfied) to 100 (extremely satisfied).3
¶At the 5-minute mark post-dose assessment on Day 1, patients selected up to 3 terms (out of 10) to describe how MIEBO felt when placed in the eyes. The majority chose silky (68.7%), smooth (67.7%), and soothing (65.7%).3
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MIEBO dosing
Not actual size.
One drop per eye, QID dosing4
Preservative free and provided
in a convenient multidose bottle (1-month supply)4,8
How to use MIEBO
MIEBO should not be administered while wearing contact lenses. Contact lenses should be removed before use and for at least 30 minutes after administration of MIEBO.4
CORRECTLY IDENTIFY MIEBO
Ensure you get the right MIEBO when searching online or in an electronic medical/health record (EMR/EHR) system.
Remember: “i before e, to treat DED.”
Storage
MIEBO should be stored at room temperature: 15-25 °C (59-77 °F). After opening, MIEBO can be used until the expiration date on the bottle.4
QID, 4 times daily.
What to expect
AQUEOUS FORMULATION
Not actual size.
Aqueous formulations have a typical drop size of ~30-50 μL3
MIEBO
Not actual size.
The small drop size (11 μL) means MIEBO may feel different from formulations containing water7
There may be no ocular sensation or blink reflex upon instillation8
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INDICATION
MIEBO® (perfluorohexyloctane ophthalmic solution) is indicated for the treatment of the signs and symptoms of dry eye disease.
IMPORTANT SAFETY INFORMATION
- MIEBO should not be administered while wearing contact lenses. Contact lenses should be removed before use and for at least 30 minutes after administration of MIEBO
- Instruct patients to instill one drop of MIEBO into each eye four times daily
- The safety and efficacy in pediatric patients below the age of 18 have not been established
- The most common ocular adverse reaction was blurred vision (1% to 3% of patients reported blurred vision and conjunctival redness)
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Click here for full Prescribing Information for MIEBO.
References: 1. Data on file. Bausch & Lomb, Inc. 2. Protzko EE, Segal BA, Korenfeld MS, Krösser S, Vittitow JL. Long-term safety and efficacy of perfluorohexyloctane ophthalmic solution for the treatment of patients with dry eye disease: the KALAHARI study. Cornea. 2024;43(9):1100-1107. doi:10.1097/ICO.0000000000003418 3. Bacharach J, Kannarr SR, Verachtert A, et al. Early effects of perfluorohexyloctane ophthalmic solution on patient-reported outcomes in dry eye disease: a prospective, open-label, multicenter study. Ophthalmol Ther. 2025;14(4):693-704. doi:10.1007/s40123-025-01097-z 4. MIEBO. Prescribing Information. Bausch & Lomb, Inc. 5. Vittitow J, Kissling R, DeCory H, Borchman D. In vitro inhibition of evaporation with perfluorohexyloctane, an eye drop for dry eye disease. Curr Ther Res Clin Exp. 2023;98:100704. doi:10.1016/j.curtheres.2023.100704 6. Agarwal P, Khun D, Krösser S, et al. Preclinical studies evaluating the effect of semifluorinated alkanes on ocular surface and tear fluid dynamics. Ocul Surf. 2019;17(2):241-249. doi:10.1016/j.jtos.2019.02.010 7. Meinert H, Roy T. Semifluorinated alkanes – a new class of compounds with outstanding properties for use in ophthalmology. Eur J Ophthalmol. 2000;10(3):189-197. doi:10.5301/EJO.2008.1838 8. Sheppard JD, Nichols KK. Dry eye disease associated with meibomian gland dysfunction: focus on tear film characteristics and the therapeutic landscape. Ophthalmol Ther. 2023;12(3):1397-1418. doi:10.1007/s40123-023-00669-1 9. Schmidl D, Bata AM, Szegedi S, et al. Influence of perfluorohexyloctane eye drops on tear film thickness in patients with mild to moderate dry eye disease: a randomized controlled clinical trial. J Ocul Pharmacol Ther. 2020;36(3):154-161. doi:10.1089/jop.2019.0092
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INDICATION AND IMPORTANT
SAFETY INFORMATION
INDICATION
MIEBO® (perfluorohexyloctane ophthalmic solution) is indicated for the treatment of the signs and symptoms of dry eye disease.
IMPORTANT SAFETY INFORMATION
- MIEBO should not be administered while wearing contact lenses. Contact lenses should be removed before use and for at least 30 minutes after administration of MIEBO
- Instruct patients to instill one drop of MIEBO into each eye four times daily
- The safety and efficacy in pediatric patients below the age of 18 have not been established
- The most common ocular adverse reaction was blurred vision (1% to 3% of patients reported blurred vision and conjunctival redness)
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Click here for full prescribing Information for MIEBO.
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